Royal Air Force Typhoon FGR4s have joined forces with France's air force in a joint strike on an underground arms cache in Syrian territory operated by the IS group, as stated by the UK's MoD.
The site, located using intelligence, was thought to be housing weapons and explosive materials, the release indicated, and was located in mountainous terrain just to the north of the historic site of Palmyra in Syria's central region.
"Our aircraft utilized Paveway IV guided bombs to strike a several approach shafts providing entry to the facility... preliminary assessments indicate the strike was effective," the MoD said.
There was no indication of any civilian casualties in the strike late on Saturday and every plane involved made a safe return, the defence officials confirmed.
The Typhoon fighters were assisted by a Voyager refuelling tanker.
Daesh - referred to as Daesh - enforced extremist governance over significant areas in Syria and Iraq prior to its 2019 collapse.
"This operation demonstrates our UK leadership, and commitment to work closely with our allies, to eradicate any re-emergence of the terrorist group and their dangerous and violent ideologies in the region," the British Defence Secretary the Defence Secretary said.
UK warplanes have carried out surveillance missions over Syrian airspace to "deter any efforts to regroup" of IS after its defeat at the climactic battle in Baghuz in 2019, the authorities noted.
"I extend gratitude to the personnel of our armed forces involved in this mission for their expertise and their valour," the Defence Secretary added. "They were among numerous British troops stationed over the festive period. This mission, to remove militants who endanger our security, demonstrates how British military are always on standby, throughout the year, protecting the UK domestically and strong abroad."
In December, the US military conducted what it called a "massive strike" on Islamic State objectives in the country, following an ambush killed two US servicemembers and a civilian linguist in the Palmyra area.
The United Nations estimates Islamic State still boasts an estimated 5,000 to 7,000 militants in Syria and Iraq.